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Article

Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia.

Epigenetics - 1 Aug 2014

Sloane Mathew A, Wong Jason W H, Perera Dilmi, Nunez Andrea C, Pimanda John E, Hawkins Nicholas J, Sieber Oliver M, Bourke Michael J, Hesson Luke B, Ward Robyn L

Abstract excerpt

In mouse models, loss of the candidate tumor suppressor gene Ubiquitin Specific Protease 44 (USP44) is associated with aneuploidy and cancer. USP44 is also transcriptionally silenced in human cancers. Here we investigated the molecular mechanism of USP44 silencing and whether this correlated with aneuploidy in colorectal adenomas. DNA methylation at the USP44 CpG island (CGI) promoter was measured using combined...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24837038
DOI: 10.4161/epi.29222
PMCID: PMC4164494

Genes

USP44

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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