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Article

The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney.

Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2005

Hong Sung-Kook, Haldin Caroline E, Lawson Nathan D, Weinstein Brant M, Dawid Igor B, Hukriede Neil A

Abstract excerpt

Mutation of the gene encoding the Mediator component thyroid hormone receptor-associated protein (TRAP)230/MED12 affects the development of multiple systems in zebrafish embryogenesis. We isolated two ethylnitrosourea-induced alleles in the gene encoding this protein and named the locus kohtalo (kto) after the homologous locus in Drosophila. Homozygous kto mutant zebrafish embryos show defects in brain, neural...

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Source

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Identifiers

PMID: 16344459
DOI: 10.1073/pnas.0509457102
PMCID: PMC1311743

Genes

MED12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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