Article
Drosophila TRAP230/240 are essential coactivators for Atonal in retinal neurogenesis.
Developmental biology - 15 Aug 2007
Lim Janghoo, Lee Ok-Kyung, Hsu Ya-Chieh, Singh Amit, Choi Kwang-Wook
Abstract excerpt
The TRAP (thyroid hormone receptor associated proteins)/Mediator complex serves as a transcriptional coactivator. In Drosophila, Kohtalo (Kto) and Skuld (Skd), homologs of TRAP subunits, TRAP230 and TRAP240, respectively, are necessary for eye development. However, the transcriptional activators that require Kto and Skd have not been identified. Here we provide evidence that Kto and Skd are essential for the...
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