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Article

A component of the transcriptional mediator complex inhibits RAS-dependent vulval fate specification in C. elegans.

Development (Cambridge, England) - 1 Jan 2003

Moghal Nadeem, Sternberg Paul W

Abstract excerpt

Negative regulation of receptor tyrosine kinase (RTK)/RAS signaling pathways is important for normal development and the prevention of disease in humans. We have used a genetic screen in C. elegans to identify genes that antagonize the activity of activated LET-23, a member of the EGFR family of RTKs. We identified two loss-of-function mutations in dpy-22, previously cloned as sop-1, that promote the ability of...

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PMID: 12441291
DOI: 10.1242/dev.00189

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A component of the transcriptional mediator complex inhibits RAS-dependent vulval fate specification in C. elegans.PMID 12441291Read ↗

A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog.Semantic proximity Read ↗

The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis.Semantic proximity Read ↗

Mutations in the Caenorhabditis elegans let-23 EGFR-like gene define elements important for cell-type specificity and function.Semantic proximity Read ↗

Components of the transcriptional Mediator complex are required for asymmetric cell division in C. elegans.Semantic proximity Read ↗

dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development.Semantic proximity Read ↗

Transcriptional control of cell-cycle quiescence during C. elegans development.Semantic proximity Read ↗

Basolateral localization of the Caenorhabditis elegans epidermal growth factor receptor in epithelial cells by the PDZ protein LIN-10.Semantic proximity Read ↗

Discovery of nonautonomous modulators of activated Ras.Semantic proximity Read ↗

A C. elegans mediator protein confers regulatory selectivity on lineage-specific expression of a transcription factor gene.Semantic proximity Read ↗

Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase.Semantic proximity Read ↗

sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction.Semantic proximity Read ↗

lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.Semantic proximity Read ↗

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