Article
Ethylnitrosourea-induced thymus-defective mutants identify roles of KIAA1440, TRRAP, and SKIV2L2 in teleost organ development.
European journal of immunology - 1 Sept 2009
Iwanami Norimasa, Okada Minoru, Hoa Vu Q, Seo Yasuhito, Mitani Hiroshi, Sasaki Takashi, Shimizu Nobuyoshi, Kondoh Hisato, Furutani-Seiki Makoto, Takahama Yousuke
Abstract excerpt
The thymus is an organ where T lymphocytes develop. Thymus development requires interactions of cells derived from three germ layers. However, the molecular mechanisms that control thymus development are not fully understood. To identify the genes that regulate thymus development, we previously carried out a large-scale screening for ethylnitrosourea-induced mutagenesis using medaka, Oryzias latipes, and...
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