Article
Combined haploid and insertional mutation screen in the zebrafish.
Genesis (New York, N.Y. : 2000) - 1 Dec 2004
Wiellette Elizabeth, Grinblat Yevgenya, Austen Matthias, Hirsinger Estelle, Amsterdam Adam, Walker Charline, Westerfield Monte, Sive Hazel
Abstract excerpt
To identify genes required for development of the brain and somites, we performed a pilot screen of gynogenetic haploid zebrafish embryos produced from mothers mutagenized by viral insertion. We describe an efficient method to identify new mutations and the affected gene. In addition, we report the results of a small-scale screen that identified five genes required for brain development, including novel alleles...
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