Block by internal Mg2+ causes voltage-dependent inactivation of Kv1.5.

doi:10.1007/s00249-006-0085-3

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Article

Block by internal Mg2+ causes voltage-dependent inactivation of Kv1.5.

European biophysics journal : EBJ - 1 Dec 2006

Claydon Thomas W, Kwan Daniel C H, Fedida David, Kehl Steven J

Abstract excerpt

Internal Mg2+ blocks many potassium channels including Kv1.5. Here, we show that internal Mg2+ block of Kv1.5 induces voltage-dependent current decay at strongly depolarised potentials that contains a component due to acceleration of C-type inactivation after pore block. The voltage-dependent current decay was fitted to a bi-exponential function (tau(fast) and tau(slow)). Without Mg2+, tau(fast) and tau(slow)...

Topics

Binding Sites
Biophysics
Electrophysiology
Humans
Ion Channel Gating
Kinetics
Kv1.5 Potassium Channel
Magnesium
Membrane Potentials
Mutation
Potassium Channels
Protein Binding

Source

Open in PubMed

Identifiers

PMID: 16902793
DOI: 10.1007/s00249-006-0085-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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