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Article

Modulation of CaV1.2 channels by Mg2+ acting at an EF-hand motif in the COOH-terminal domain.

The Journal of general physiology - 1 Oct 2005

Brunet Sylvain, Scheuer Todd, Klevit Rachel, Catterall William A

Abstract excerpt

Magnesium levels in cardiac myocytes change in cardiovascular diseases. Intracellular free magnesium (Mg(i)) inhibits L-type Ca(2+) currents through Ca(V)1.2 channels in cardiac myocytes, but the mechanism of this effect is unknown. We hypothesized that Mg(i) acts through the COOH-terminal EF-hand of Ca(V)1.2. EF-hand mutants were engineered to have either decreased (D1546A/N/S/K) or increased (K1543D and K1539D)...

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Identifiers

PMID: 16157690
DOI: 10.1085/jgp.200509333
PMCID: PMC2266622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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