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Article

Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure.

American journal of physiology. Gastrointestinal and liver physiology - 1 Mar 2008

Pfluger Paul T, Kirchner Henriette, Günnel Susanne, Schrott Brigitte, Perez-Tilve Diego, Fu Sheng, Benoit Stephen C, Horvath Tamas, Joost Hans-Georg, Wortley Katherine E, Sleeman Mark W, Tschöp Matthias H

Abstract excerpt

Administration of chemically synthesized ghrelin (Ghr) peptide has been shown to increase food intake and body adiposity in most species. However, the biological role of endogenous Ghr in the molecular control of energy metabolism is far less understood. Mice deficient for either Ghr or its receptor (the growth hormone secretagogue receptor, GHS-R1a) seem to exhibit enhanced protection against high-fat...

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Identifiers

PMID: 18048479
DOI: 10.1152/ajpgi.00321.2007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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