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Article

Absence of ghrelin protects against early-onset obesity.

The Journal of clinical investigation - 1 Dec 2005

Wortley Katherine E, del Rincon Juan-Pablo, Murray Jane D, Garcia Karen, Iida Keiji, Thorner Michael O, Sleeman Mark W

Abstract excerpt

The gut peptide ghrelin, the endogenous ligand for the growth hormone secretagogue receptor, has been implicated not only in the regulation of pituitary growth hormone (GH) secretion but in a number of endocrine and nonendocrine functions, including appetitive behavior and carbohydrate substrate utilization. Nevertheless, recent genetic studies have failed to show any significant defects in GH levels, food...

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Identifiers

PMID: 16322795
DOI: 10.1172/JCI26003
PMCID: PMC1297252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Absence of ghrelin protects against early-onset obesity.PMID 16322795Read ↗

Mice lacking ghrelin receptors resist the development of diet-induced obesity.Semantic proximity Read ↗

Ablations of ghrelin and ghrelin receptor exhibit differential metabolic phenotypes and thermogenic capacity during aging.Semantic proximity Read ↗

Genetic deletion of the ghrelin receptor (GHSR) impairs growth and blunts endocrine response to fasting in Ghsr-IRES-Cre mice.Semantic proximity Read ↗

Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance.Semantic proximity Read ↗

Rats with a truncated ghrelin receptor (GHSR) do not respond to ghrelin, and show reduced intake of palatable, high-calorie food.Semantic proximity Read ↗

The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction.Semantic proximity Read ↗

Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse.Semantic proximity Read ↗

The Role of Insulin-like Growth Factor-1 (IGF-1) in the Control of Neuroendocrine Regulation of GrowthSemantic proximity Read ↗

GH and IGF1: roles in energy metabolism of long-living GH mutant mice.Semantic proximity Read ↗

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice.Semantic proximity Read ↗

Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure.Semantic proximity Read ↗

Enhanced responsiveness of Ghsr Q343X rats to ghrelin results in enhanced adiposity without increased appetite.Semantic proximity Read ↗

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