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Article

Effects of growth hormone-releasing hormone gene targeted ablation on ghrelin-induced feeding.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 1 Dec 2017

Recinella Lucia, Leone Sheila, Ferrante Claudio, Chiavaroli Annalisa, Shohreh Rugia, Di Nisio Chiara, Vacca Michele, Orlando Giustino, Salvatori Roberto, Brunetti Luigi

Abstract excerpt

Impairment of growth hormone (GH) signaling has been associated with increased feeding and adiposity. The gastric hormone ghrelin, in addition to its GH-secretagogue effects, stimulates food intake after both central and peripheral administration. In the present study we further investigated the feeding regulatory role of the ghrelin-GH axis in a mouse model of isolated GH deficiency due to targeted ablation of...

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Source

Identifiers

PMID: 29121520
DOI: 10.1016/j.ghir.2017.10.007

Genes

CRH
GHRH
NPY
POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effects of growth hormone-releasing hormone gene targeted ablation on ghrelin-induced feeding.PMID 29121520Read ↗

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A Mouse with Targeted Ablation of the Growth Hormone-Releasing Hormone Gene: A New Model of Isolated Growth Hormone DeficiencySemantic proximity Read ↗

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