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Article

Genetic deletion of the ghrelin receptor (GHSR) impairs growth and blunts endocrine response to fasting in Ghsr-IRES-Cre mice.

Molecular metabolism - 1 Sept 2021

Peris-Sampedro Fiona, Stoltenborg Iris, Le May Marie V, Zigman Jeffrey M, Adan Roger A H, Dickson Suzanne L

Abstract excerpt

OBJECTIVE: The orexigenic hormone ghrelin exerts its physiological effects by binding to and activating the growth hormone secretagogue receptor (GHSR). The recent development of a Ghsr-IRES-Cre knock-in mouse line has enabled to genetically access GHSR-expressing neurons. Inserting a Cre construct using a knock-in strategy, even when following an upstream internal ribosome entry site (IRES) can, however,...

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Identifiers

PMID: 33798772
DOI: 10.1016/j.molmet.2021.101223
PMCID: PMC8102639

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