Article
Bi-directional allelic recognition of the human minor histocompatibility antigen HB-1 by cytotoxic T lymphocytes.
European journal of immunology - 1 Oct 2002
Dolstra Harry, de Rijke Björn, Fredrix Hanny, Balas Antonio, Maas Frans, Scherpen Frank, Aviles Maria J, Vicario Jose L, Beekman Nico J, Ossendorp Ferry, de Witte Theo M, van de Wiel-van Kemenade Elly
Abstract excerpt
Human minor histocompatibility antigens (mHag) are target antigens of the graft-versus-leukemia response observed after allogeneic HLA-identical stem cell transplantation. We previously defined the molecular nature of the B cell lineage-specific mHag HB-1. The CTL epitope was identified as the decamer peptide EEKRGSLHVW presented in the context of HLA-B44. The HB-1 antigen is encoded by a locus of yet unknown...
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