Article
Identification of 4 new HLA-DR-restricted minor histocompatibility antigens as hematopoietic targets in antitumor immunity.
Blood - 22 Oct 2009
Stumpf Anita N, van der Meijden Edith D, van Bergen Cornelis A M, Willemze Roel, Falkenburg J H Frederik, Griffioen Marieke
Abstract excerpt
Potent graft-versus-leukemia (GVL) effects can be mediated by donor-derived T cells recognizing minor histocompatibility antigens (mHags) in patients treated with donor lymphocyte infusion (DLI) for relapsed hematologic malignancies after HLA-matched allogeneic stem cell transplantation (alloSCT). Donor-derived T cells, however, may not only induce GVL, but also mediate detrimental graft-versus-host disease...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
