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Exploiting T cells specific for human minor histocompatibility antigens for therapy of leukemia

8 Feb 2011

Abstract excerpt

Minor histocompatibility (H) antigens are major targets of a graft-versus-leukemia (GVL) effect mediated by donor CD8(+) and CD4(+) T cells following allogeneic hematopoietic cell transplantation (HCT) between human leukocyte antigen identical individuals. In the 15 years since the first molecular characterization of human minor H antigens, significant strides in minor H antigen discovery have been made as a...

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PMID: 21301477
DOI: 10.1038/icb.2010.124

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