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Article

Role of sigma-1 receptors in neurodegenerative diseases

12 Dec 2014

Abstract excerpt

Neurodegenerative diseases with distinct genetic etiologies and pathological phenotypes appear to share common mechanisms of neuronal cellular dysfunction, including excitotoxicity, calcium dysregulation, oxidative damage, ER stress and mitochondrial dysfunction. Glial cells, including microglia and astrocytes, play an increasingly recognized role in both the promotion and prevention of neurodegeneration. Sigma...

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PMID: 25704014
DOI: 10.1016/j.jphs.2014.12.005

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