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Article

Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.

Neurobiology of aging - 1 May 2012

Erlich Porat M, Lunetta Kathryn L, Cupples L Adrienne, Abraham Carmela R, Green Robert C, Baldwin Clinton T, Farrer Lindsay A

Abstract excerpt

Previous studies have shown association of single nucleotide polymorphisms (SNPs) in 3 contiguous genes (PON1, PON2, and PON3) encoding paraoxonase with risk of Alzheimer disease (AD). We evaluated the association of serum paraoxonase activity measured by phenyl acetate (PA) and thiobutyl butyrolactone (TBBL) with risk of AD and with 26 SNPs spanning the PON gene cluster in 266 AD cases and 306 sibling controls...

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Identifiers

PMID: 20980077
DOI: 10.1016/j.neurobiolaging.2010.08.003
PMCID: PMC3034817

Genes

PON1
PON2
PON3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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