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Article

Paraoxonase 1 gene polymorphisms and dementia in humans.

Neuroscience letters - 18 Mar 2004

Helbecque Nicole, Cottel Dominique, Codron Valérie, Berr Claudine, Amouyel Philippe

Abstract excerpt

Several clinical and epidemiological studies suggest that Alzheimer's disease (AD) and vascular dementia share common risk factors. Oxidative stress is one of these well recognized factors. It can result from an excess of free-radical activity and impaired antioxidant defenses. Paraoxonase (PON1), a component of high density lipoproteins, has antioxidative potential and was previously associated with an increased...

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Source

Identifiers

PMID: 15016430
DOI: 10.1016/j.neulet.2003.12.100

Genes

PON1
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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