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Article

Polymorphisms at the paraoxonase 1 L55M and Q192R loci affect the pathophysiology of Alzheimer's disease: emphasis on the cholinergic system and beta-amyloid levels.

Neuro-degenerative diseases - 1 Jan 2008

Leduc Valerie, Poirier Judes

Abstract excerpt

BACKGROUND: Paraoxonase 1 (PON1) functions to protect the cholinergic system against nerve gases and the organophosphate family of pesticides. Recent studies have shown that polymorphisms at the PON1 L55M and Q192R loci might affect individual susceptibility to experience-derived and environmental events such as the exposure to inhibitors of cholinesterase (ChEIs). OBJECTIVE: ChEI therapy being the treatment of...

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Identifiers

PMID: 18322397
DOI: 10.1159/000113709

Genes

PON1
CHAT

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Polymorphisms at the paraoxonase 1 L55M and Q192R loci affect the pathophysiology of Alzheimer's disease: emphasis on the cholinergic system and beta-amyloid levels.PMID 18322397Read ↗

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