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Article

Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation.

Molecular endocrinology (Baltimore, Md.) - 1 Sept 2003

Cook Laurie B, Zhu Chang-Cheng, Hinkle Patricia M

Abstract excerpt

These studies were designed to characterize ubiquitination of the G protein-coupled TRH receptor (TRHR). TRHRs and ubiquitin coprecipitated with antibodies to either receptor or ubiquitin in Chinese hamster ovary or pituitary GHFT cells. Inhibition of the proteasome with MG-132 resulted in an accumulation of total TRHRs and the appearance of a small amount of cytosolic receptor. MG-132 caused an increase in newly...

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Source

Identifiers

PMID: 12805411
DOI: 10.1210/me.2003-0073

Genes

TRHR
TRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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