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Article

Separate ion pathways in a Cl-/H+ exchanger.

The Journal of general physiology - 1 Dec 2005

Accardi Alessio, Walden Michael, Nguitragool Wang, Jayaram Hariharan, Williams Carole, Miller Christopher

Abstract excerpt

CLC-ec1 is a prokaryotic CLC-type Cl(-)/H+ exchange transporter. Little is known about the mechanism of H+ coupling to Cl-. A critical glutamate residue, E148, was previously shown to be required for Cl(-)/H+ exchange by mediating proton transfer between the protein and the extracellular solution. To test whether an analogous H+ acceptor exists near the intracellular side of the protein, we performed a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16316975
DOI: 10.1085/jgp.200509417
PMCID: PMC2266597

Genes

CLC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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