Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proton transport pathway in the ClC Cl-/H+ antiporter.

Biophysical journal - 8 Jul 2009

Wang Dong, Voth Gregory A

Abstract excerpt

A fundamental question concerning the ClC Cl-/H+ antiporters is the nature of their proton transport (PT) pathway. We addressed this issue by using a novel computational methodology capable of describing the explicit PT dynamics in the ClC-ec1 protein. The main result is that the Glu203 residue delivers a proton from the intracellular solution to the core of ClC-ec1 via a rotation of its side chain and subsequent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Antiporters
Share to Biological Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Computer Simulation

Share to Models, Biological

Share to Models, Molecular

Share to Protons

Source

Open in PubMed Open full text

Identifiers

PMID: 19580750
DOI: 10.1016/j.bpj.2009.04.038
PMCID: PMC2711357

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proton transport pathway in the ClC Cl-/H+ antiporter.PMID 19580750Read ↗

Separate ion pathways in a Cl-/H+ exchanger.Semantic proximity Read ↗

Intracellular proton access in a Cl(-)/H(+) antiporter.Semantic proximity Read ↗

A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl-/H+ transport cycle.Semantic proximity Read ↗

Intracellular proton regulation of ClC-0.Semantic proximity Read ↗

The role of protons in fast and slow gating of the Torpedo chloride channel ClC-0.Semantic proximity Read ↗

Mutations in an intracellular vestibule that bifurcates from the pore of ClC-1 chloride ion channels affect anion permeationSemantic proximity Read ↗

Molecular Simulations Meet Personalized Medicine. The Mechanism of Action of ClC-5 Antiporter and the Origin of Dent’s DiseaseSemantic proximity Read ↗

Uncoupling and turnover in a Cl-/H+ exchange transporter.Semantic proximity Read ↗

Structure of a slow CLC Cl⁻/H+ antiporter from a cyanobacterium.Semantic proximity Read ↗

Exploring the gating mechanism in the ClC chloride channel via metadynamics.Semantic proximity Read ↗

Anion pathway and potential energy profiles along curvilinear bacterial ClC Cl- pores: electrostatic effects of charged residues.Semantic proximity Read ↗

Alternative proton-binding site and long-distance coupling in Escherichia coli sodium-proton antiporter NhaA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.