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Article

Synergistic substrate binding determines the stoichiometry of transport of a prokaryotic H(+)/Cl(-) exchanger.

Nature structural & molecular biology - 8 Apr 2012

Picollo Alessandra, Xu Yanyan, Johner Niklaus, Bernèche Simon, Accardi Alessio

Abstract excerpt

Active exchangers dissipate the gradient of one substrate to accumulate nutrients, export xenobiotics and maintain cellular homeostasis. Mechanistic studies have suggested that two fundamental properties are shared by all exchangers: substrate binding is antagonistic, and coupling is maintained b...

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Identifiers

PMID: 22484316
DOI: 10.1038/nsmb.2277
PMCID: PMC3348462

Genes

CLC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22484316-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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