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Article

Shuttling mechanism of peroxisome targeting signal type 1 receptor Pex5: ATP-independent import and ATP-dependent export.

Molecular and cellular biology - 1 Dec 2005

Miyata Non, Fujiki Yukio

Abstract excerpt

Peroxisomal matrix proteins are posttranslationally imported into peroxisomes with the peroxisome-targeting signal 1 receptor, Pex5. The longer isoform of Pex5, Pex5L, also transports Pex7-PTS2 protein complexes. After unloading the cargoes, Pex5 returns to the cytosol. To address molecular mechanisms underlying Pex5 functions, we constructed a cell-free Pex5 translocation system with a postnuclear supernatant...

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Identifiers

PMID: 16314507
DOI: 10.1128/MCB.25.24.10822-10832.2005
PMCID: PMC1316942

Genes

PEX1
PEX26
PEX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Shuttling mechanism of peroxisome targeting signal type 1 receptor Pex5: ATP-independent import and ATP-dependent export.PMID 16314507Read ↗

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Cysteine ubiquitination of PTS1 receptor Pex5p regulates Pex5p recycling.Semantic proximity Read ↗

Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol.Semantic proximity Read ↗

Functional domains and dynamic assembly of the peroxin Pex14p, the entry site of matrix proteins.Semantic proximity Read ↗

Molecular mechanisms of import of peroxisome-targeting signal type 2 (PTS2) proteins by PTS2 receptor Pex7p and PTS1 receptor Pex5pL.Semantic proximity Read ↗

The PEX1 ATPase Stabilizes PEX6 and Plays Essential Roles in Peroxisome Biology.Semantic proximity Read ↗

The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo.Semantic proximity Read ↗

Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts.Semantic proximity Read ↗

Peroxisome import stress impairs ribosome biogenesis and induces integrative stress response through eIF2α phosphorylationSemantic proximity Read ↗

The import receptor Pex7p and the PTS2 targeting sequence.Semantic proximity Read ↗

PEX1 <sup>G843D</sup> remains functional in peroxisome biogenesis but is rapidly degraded by the proteasomeSemantic proximity Read ↗

Alternative splicing suggests extended function of PEX26 in peroxisome biogenesis.Semantic proximity Read ↗

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