Article
Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts.
Autophagy - 1 Jan 2015
Nordgren Marcus, Francisco Tânia, Lismont Celien, Hennebel Lore, Brees Chantal, Wang Bo, Van Veldhoven Paul P, Azevedo Jorge E, Fransen Marc
Abstract excerpt
Peroxisomes are ubiquitous cell organelles essential for human health. To maintain a healthy cellular environment, dysfunctional and superfluous peroxisomes need to be selectively removed. Although emerging evidence suggests that peroxisomes are mainly degraded by pexophagy, little is known about the triggers and molecular mechanisms underlying this process in mammalian cells. In this study, we show that PEX5...
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