Article
Functional domains and dynamic assembly of the peroxin Pex14p, the entry site of matrix proteins.
The Journal of biological chemistry - 14 Apr 2006
Itoh Ryota, Fujiki Yukio
Abstract excerpt
The 41-kDa membrane-anchored peroxin Pex14p functions as the peroxisome targeting signal (PTS) receptor-mediated, initial import site for matrix proteins. We here identify the functional domains of Pex14p involved in the assembly of import site subcomplexes. The minimal region of Pex14p required for restoring impaired protein import in pex14 Chinese hamster ovary cell mutant lies at residues 21-260 in the primary...
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