Article

Peroxisome import stress impairs ribosome biogenesis and induces integrative stress response through eIF2α phosphorylation

2020-11-20

Abstract excerpt

Peroxisome biogenesis diseases (PBDs) are characterized by global defects in peroxisomal function and can result in severe brain, liver, kidney, and bone malfunctions. PBDs are due to mutations in peroxisome biogenesis factors (PEX genes) that are responsible for peroxisome assembly and function. Increasing evidence suggests that peroxisome import functions decline during aging. However, the transcriptome profilin...

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Literature Corpus work: d6b35311-e9c0-5720-b169-28f02a56ed15
DOI: 10.1101/2020.11.19.390609

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