Molecular mechanisms of import of peroxisome-targeting signal type 2 (PTS2) proteins by PTS2 receptor Pex7p and PTS1 receptor Pex5pL.

doi:10.1074/jbc.M607178200

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Article

Molecular mechanisms of import of peroxisome-targeting signal type 2 (PTS2) proteins by PTS2 receptor Pex7p and PTS1 receptor Pex5pL.

The Journal of biological chemistry - 8 Dec 2006

Mukai Satoru, Fujiki Yukio

Abstract excerpt

In the present study, we investigated molecular mechanisms underlying the import of peroxisome-targeting signal type 2 (PTS2) proteins into peroxisomes. Purified Chinese hamster Pex7p that had been expressed in an Sf9/baculovirus system was biologically active in several assays such as those for PTS2 binding and assessing the restoration of the impaired PTS2 protein import in Chinese hamster ovary (CHO) pex7...

Topics

Animals
Baculoviridae
Biological Transport, Active
CHO Cells
Cell Line
Cricetinae
Cysteine
Humans
In Vitro Techniques
Models, Biological
Mutation
Peroxisomal Targeting Signal 2 Receptor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peroxisome-Targeting Signal 1 Receptor

Peroxisomes

Protein Conformation

Rats

Receptors, Cytoplasmic and Nuclear

Recombinant Fusion Proteins

Source

Open in PubMed

Identifiers

PMID: 17040904
DOI: 10.1074/jbc.M607178200

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Molecular mechanisms of import of peroxisome-targeting signal type 2 (PTS2) proteins by PTS2 receptor Pex7p and PTS1 receptor Pex5pL.PMID 17040904Read ↗

The import receptor Pex7p and the PTS2 targeting sequence.Semantic proximity Read ↗

Interaction defect of the medium isoform of PTS1-receptor Pex5p with PTS2-receptor Pex7p abrogates the PTS2 protein import into peroxisomes in mammals.Semantic proximity Read ↗

Intracellular localization, function, and dysfunction of the peroxisome-targeting signal type 2 receptor, Pex7p, in mammalian cells.Semantic proximity Read ↗

Pex5p stabilizes Pex14p: a study using a newly isolated pex5 CHO cell mutant, ZPEG101.Semantic proximity Read ↗

Peroxisome targeting signal type 1 (PTS1) receptor is involved in import of both PTS1 and PTS2: studies with PEX5-defective CHO cell mutants.Semantic proximity Read ↗

Functional studies on human Pex7p: subcellular localization and interaction with proteins containing a peroxisome-targeting signal type 2 and other peroxins.Semantic proximity Read ↗

Saccharomyces cerevisiae PTS1 receptor Pex5p interacts with the SH3 domain of the peroxisomal membrane protein Pex13p in an unconventional, non-PXXP-related manner.Semantic proximity Read ↗

Interaction of Pex5p, the type 1 peroxisome targeting signal receptor, with the peroxisomal membrane proteins Pex14p and Pex13p.Semantic proximity Read ↗

Shuttling mechanism of peroxisome targeting signal type 1 receptor Pex5: ATP-independent import and ATP-dependent export.Semantic proximity Read ↗

Cysteine ubiquitination of PTS1 receptor Pex5p regulates Pex5p recycling.Semantic proximity Read ↗

A mobile PTS2 receptor for peroxisomal protein import in Pichia pastoris.Semantic proximity Read ↗

Peroxin Pex14p is the key component for coordinated autophagic degradation of mammalian peroxisomes by direct binding to LC3-II.Semantic proximity Read ↗

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