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Article

Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation.

Molecular and cellular biology - 1 Dec 2005

Pandey Pradeep K, Udayakumar T S, Lin Xinjie, Sharma Dipali, Shapiro Paul S, Fondell Joseph D

Abstract excerpt

The TRAP/Mediator coactivator complex serves as a molecular bridge between gene-specific activators and RNA polymerase II. TRAP220/Med1 is a key component of TRAP/Mediator that targets the complex to nuclear hormone receptors and other types of activators. We show here that human TRAP220/Med1 is a specific substrate for extracellular signal-regulated kinase (ERK) of the mitogen-activated protein kinase (MAPK)...

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Identifiers

PMID: 16314496
DOI: 10.1128/MCB.25.24.10695-10710.2005
PMCID: PMC1316958

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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