Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of target genes for the CDK subunits of the Mediator complex

27 Nov 2011

Abstract excerpt

Mediator is a large complex containing up to 30 subunits that consist of four modules each: head, middle, tail and CDK/Cyclin. Recent studies have shown that CDK8, a subunit of the CDK/Cyclin module, is one of the key subunits of Mediator that mediates its pivotal roles in transcriptional regulation. In addition to CDK8, CDK19 was identified in human Mediator with a great deal of similarity to CDK8 but was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to RNA modifications and cancer
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22117896
DOI: 10.1111/j.1365-2443.2011.01565.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of target genes for the CDK subunits of the Mediator complexPMID 22117896Read ↗

Molecular and in vivo Functions of the CDK8 and CDK19 Kinase ModulesSemantic proximity Read ↗

Insights into the regulatory role and clinical relevance of mediator subunit, MED12, in human diseasesSemantic proximity Read ↗

Cyclin-Dependent Kinase 8 Positively Cooperates with Mediator To Promote Thyroid Hormone Receptor-Dependent Transcriptional ActivationSemantic proximity Read ↗

The two faces of Cdk8, a positive/negative regulator of transcription.Semantic proximity Read ↗

A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 ResponseSemantic proximity Read ↗

The Mediator Complex: Progress over the Past DecadeSemantic proximity Read ↗

Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate CancerSemantic proximity Read ↗

Comprehensive analysis of the transcriptional profile of the Mediator complex across human cancer typesSemantic proximity Read ↗

Potential roles of mediator Complex Subunit 13 in Cardiac DiseasesSemantic proximity Read ↗

Direct interaction of RNA polymerase II and mediator required for transcription in vivo.Semantic proximity Read ↗

Identifying Cancers Impacted by CDK8/19Semantic proximity Read ↗

A precisely positioned MED12 activation helix stimulates CDK8 kinase activitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.