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Article

The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation.

Nucleic acids research - 1 Jan 2007

Chen Wei, Roeder Robert G

Abstract excerpt

The MED1/TRAP220 subunit of the Mediator plays a key role in facilitating ligand-dependent interactions of this multisubunit coactivator complex with nuclear receptors through their ligand binding domains. The isolated MED1/TRAP220 protein previously was shown to interact with glucocorticoid rece...

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Source

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Identifiers

PMID: 17827210
DOI: 10.1093/nar/gkm661
PMCID: PMC2094069

Genes

MED1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17827210-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation.PMID 17827210Read ↗

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Molecular determinants of the interactions between LXR/RXR heterodimers and TRAP220.Semantic proximity Read ↗

Mouse gene trap approach: identification of novel genes and characterization of their biological functions.Semantic proximity Read ↗

Loss of Med1/TRAP220 promotes the invasion and metastasis of human non-small-cell lung cancer cells by modulating the expression of metastasis-related genesSemantic proximity Read ↗

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