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Article

Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT.

The Journal of cell biology - 6 Oct 2008

Stanya Kristopher J, Liu Yu, Means Anthony R, Kao Hung-Ying

Abstract excerpt

Silencing mediator for retinoic acid and thyroid hormone receptor (SMRT) is a transcriptional corepressor that participates in diverse signaling pathways and human diseases. However, regulation of SMRT stability remains largely unexplored. We show that the peptidyl-prolyl isomerase Pin1 interacts with SMRT both in vitro and in mammalian cells. This interaction requires the WW domain of Pin1 and SMRT...

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Identifiers

PMID: 18838553
DOI: 10.1083/jcb.200806172
PMCID: PMC2557042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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