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Article

Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors.

Molecular and cellular biology - 1 Sept 2004

Malik Sohail, Guermah Mohamed, Yuan Chao-Xing, Wu Weizhen, Yamamura Soichiro, Roeder Robert G

Abstract excerpt

The TRAP/Mediator complex serves as a coactivator for many transcriptional activators, including nuclear receptors such as the thyroid hormone receptor (TR) that targets the TRAP220 subunit. The critical but selective function of TRAP220 is evidenced by the embryonic lethal phenotype of Trap220(-)(/)(-) mice and by the observation that Trap220(-)(/)(-) fibroblasts (isolated before embryonic death) are impaired in...

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Identifiers

PMID: 15340084
DOI: 10.1128/MCB.24.18.8244-8254.2004
PMCID: PMC515042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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