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Article

Novel functions of thyroid hormone receptor mutants: beyond nucleus-initiated transcription.

Steroids - 1 Feb 2007

Furuya Fumihiko, Ying Hao, Zhao Li, Cheng Sheue-yann

Abstract excerpt

Study of molecular actions of thyroid hormone receptor beta (TRbeta) mutants in vivo has been facilitated by creation of a mouse model (TRbetaPV mouse) that harbors a knockin mutant of TRbeta (denoted PV). PV, which was identified in a patient with resistance to thyroid hormone, has lost T3 binding activity and transcription capacity. The striking phenotype of thyroid cancer exhibited by TRbeta(PV/PV) mice has...

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Identifiers

PMID: 17169389
DOI: 10.1016/j.steroids.2006.11.005
PMCID: PMC2794798

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SRC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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