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Article

Site-directed mutagenesis of HLA molecules reveals the functional epitope of a human HLA-A1/A36-specific monoclonal antibody.

HLA - 1 Feb 2023

Meng Tina, Bezstarosti Suzanne, Singh Ujjwala, Yap Michelle, Scott Laura, Petrosyan Naiiry, Quiroz Fred, Eps Ned Van, Hui Eric Ka-Wai, Suh David, Zhu Quansheng, Pei Rui, Kramer Cynthia S M, Claas Frans H J, Lowe David, Heidt Sebastiaan

Abstract excerpt

Eplet 44KM is currently listed in the HLA Epitope Registry but does not adhere to the eplet definition of an amino acid configuration within a 3.5 Å radius. Eplet 44KM has been previously redefined to the antibody-verified reactivity pattern 44K/150V/158V, based on reactivity analysis of monoclonal antibody VDK1D12. Since the three residues are always simultaneously present on common HLA alleles, methods to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36401817
DOI: 10.1111/tan.14895
PMCID: PMC10099858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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