Article
Accurate determination of epitope for antibodies with unknown 3D structures.
mAbs - 1 Jan 2000
Tahir Shifa, Bourquard Thomas, Musnier Astrid, Jullian Yann, Corde Yannick, Omahdi Zakaria, Mathias Laetitia, Reiter Eric, Crépieux Pascale, Bruneau Gilles, Poupon Anne
Abstract excerpt
MAbTope is a docking-based method for the determination of epitopes. It has been used to successfully determine the epitopes of antibodies with known 3D structures. However, during the antibody discovery process, this structural information is rarely available. Although we already have evidence that homology models of antibodies could be used instead of their 3D structure, the choice of the template, the...
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