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Article

E6AP and calmodulin reciprocally regulate estrogen receptor stability.

The Journal of biological chemistry - 27 Jan 2006

Li Lu, Li Zhigang, Howley Peter M, Sacks David B

Abstract excerpt

Estrogen promotes the proliferation of human breast epithelial cells by interacting with the estrogen receptor (ER). Physiological responses of cells to estrogen are regulated in part by degradation of the ER. Previous studies revealed that calmodulin binds directly to the ER, thereby enhancing its stability. Consistent with these findings, cell-permeable calmodulin antagonists dramatically reduced the number of...

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PMID: 16314411
DOI: 10.1074/jbc.M508545200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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