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Article

Melatonin, an endogenous-specific inhibitor of estrogen receptor alpha via calmodulin.

The Journal of biological chemistry - 10 Sept 2004

del Río Beatriz, García Pedrero Juana M, Martínez-Campa Carlos, Zuazua Pedro, Lazo Pedro S, Ramos Sofía

Abstract excerpt

Melatonin is an indole hormone produced mainly by the pineal gland. We have previously demonstrated that melatonin interferes with estrogen (E(2)) signaling in MCF7 cells by impairing estrogen receptor (ER) pathways. Here we present the characterization of its mechanism of action showing that melatonin is a specific inhibitor of E(2)-induced ERalpha-mediated transcription in both estrogen response element- and...

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Source

Identifiers

PMID: 15229223
DOI: 10.1074/jbc.M403140200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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