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Article

Calcium/calmodulin inhibition of transcriptional activity of E-proteins by prevention of their binding to DNA.

The Journal of biological chemistry - 24 Sept 2004

Saarikettu Juha, Sveshnikova Natalia, Grundström Thomas

Abstract excerpt

The Ca2+ sensor protein calmodulin can interact with the DNA binding basic helix-loop-helix (bHLH) domain of E12, E47, and SEF2-1 (E2-2), which belong to the E-protein subclass of bHLH transcription factors. This interaction inhibits the DNA binding of these bHLH proteins in vitro, and an ionophore that increases intracellular Ca2+ can inhibit transcriptional activation by the E-proteins. Here we have attempted...

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PMID: 15280352
DOI: 10.1074/jbc.M408120200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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