Article
Calmodulin promotes matrix metalloproteinase 9 production and cell migration by inhibiting the ubiquitination and degradation of TBC1D3 oncoprotein in human breast cancer cells.
Oncotarget - 30 May 2017
Zhao Huzi, Zhang Lina, Zhang Yongchen, Zhao Lei, Wan Qing, Wang Bei, Bu Xiaodong, Wan Meiling, Shen Chuanlu
Abstract excerpt
The hominoid oncoprotein TBC1D3 enhances growth factor (GF) signaling and GF signaling, conversely, induces the ubiquitination and subsequent degradation of TBC1D3. However, little is known regarding the regulation of this degradation, and the role of TBC1D3 in the progression of tumors has also not been defined. In the present study, we demonstrated that calmodulin (CaM), a ubiquitous cellular calcium sensor,...
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