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Article

Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin.

The Journal of biological chemistry - 28 Apr 2006

Huang Ying, Niwa Jun-ichi, Sobue Gen, Breitwieser Gerda E

Abstract excerpt

Calcium-sensing receptors (CaR) contribute to regulation of systemic calcium homeostasis by activation of G(q)- and G(i)-linked signaling pathways in the parathyroids, kidney, and intestine. Little is known about the mechanisms regulating CaR synthesis and degradation. Screening of a human kidney yeast two-hybrid library identified the E3 ubiquitin ligase dorfin as a binding partner for the intracellular carboxyl...

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Identifiers

PMID: 16513638
DOI: 10.1074/jbc.M513552200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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