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Article

Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6.

The Journal of biological chemistry - 28 Oct 2005

Shen Chuanlu, Ye Ying, Robertson Sarah E, Lau Alan W, Mak Don-On D, Chou Margaret M

Abstract excerpt

The TRE17 (USP6/TRE-2) oncogene induces tumorigenesis in both humans and mice. However, little is known regarding its regulation or mechanism of transformation. TRE17 encodes a TBC (Tre-2/Bub2/Cdc16)/Rab GTPase-activating protein homology domain at its N terminus and a ubiquitin-specific protease at its C terminus. In the current study, we identified the ubiquitous calcium (Ca2+)-binding protein calmodulin (CaM)...

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PMID: 16127172
DOI: 10.1074/jbc.M505220200

Genes

USP6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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