Article
Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability.
Molecular and cellular biology - 1 Jan 1997
Kubbutat M H, Vousden K H
Abstract excerpt
The p53 tumor suppressor protein is activated in cells in response to DNA damage and prevents the replication of cells sustaining genetic damage by inducing a cell cycle arrest or apoptosis. Activation of p53 is accompanied by stabilization of the protein, resulting in accumulation to high levels within the cell. p53 is normally degraded through the proteasome following ubiquitination, although the mechanisms...
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