Article
Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion.
Breast cancer research : BCR - 18 Aug 2017
Qin Sisi, Ingle James N, Liu Mohan, Yu Jia, Wickerham D Lawrence, Kubo Michiaki, Weinshilboum Richard M, Wang Liewei
Abstract excerpt
BACKGROUND: We previously performed a case-control genome-wide association study in women treated with selective estrogen receptor modulators (SERMs) for breast cancer prevention and identified single nucleotide polymorphisms (SNPs) in ZNF423 as potential biomarkers for response to SERM therapy. The ZNF423rs9940645 SNP, which is approximately 200 bp away from the estrogen response elements, resulted in the SNP,...
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