Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A beta-catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors.

Carcinogenesis - 1 Jan 2005

Loeppen Sandra, Koehle Christoph, Buchmann Albrecht, Schwarz Michael

Abstract excerpt

Phenobarbital (PB) is a model tumor promoter in the rodent liver. In the mouse, the promotional effect of PB results from a selective stimulation of clonal outgrowth of hepatocytes harboring activating mutations in the beta-catenin (catnb) gene. Glutamine synthetase (GS), a downstream target in the Wnt/beta-catenin/T-cell factor (TCF) signaling pathway, is strongly up-regulated in catnb-mutated mouse liver tumors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoskeletal Proteins

Share to Glutamate-Ammonia Ligase

Share to Isoenzymes

Share to Liver Neoplasms, Experimental

Share to Trans-Activators

Share to Transcriptional Activation

Source

Identifiers

PMID: 15471898
DOI: 10.1093/carcin/bgh298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A beta-catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors.PMID 15471898Read ↗

Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital.Semantic proximity Read ↗

PCB 153, a non-dioxin-like tumor promoter, selects for beta-catenin (Catnb)-mutated mouse liver tumors.Semantic proximity Read ↗

Analysis of β-catenin gene mutations and gene expression in liver tumours of C57BL/10J mice produced by chronic administration of sodium phenobarbital.Semantic proximity Read ↗

Activation of beta-catenin during hepatocarcinogenesis in transgenic mouse models: relationship to phenotype and tumor grade.Semantic proximity Read ↗

Beta-catenin mutations and protein accumulation in all hepatoblastomas examined from B6C3F1 mice treated with anthraquinone or oxazepam.Semantic proximity Read ↗

β-catenin Mutations Are Not Involved in Early-stage Hepatocarcinogenesis Induced by Protoporphyrinogen Oxidase Inhibitors in Mice.Semantic proximity Read ↗

Overview of the molecular biology of hepatocellular neoplasms and hepatoblastomas of the mouse liver.Semantic proximity Read ↗

Genotype-phenotype relationships in hepatocellular tumors from mice and man.Semantic proximity Read ↗

Tumor promotion and inhibition by phenobarbital in livers of conditional Apc-deficient mice.Semantic proximity Read ↗

Gene expression and mutation assessment provide clues of genetic and epigenetic mechanisms in liver tumors of oxazepam-exposed mice.Semantic proximity Read ↗

High Frequency of β-Catenin Mutations in Mouse Hepatocellular Carcinomas Induced by a Nongenotoxic Constitutive Androstane Receptor Agonist.Semantic proximity Read ↗

Expression of potential beta-catenin targets, cyclin D1, c-Jun, c-Myc, E-cadherin, and EGFR in chemically induced hepatocellular neoplasms from B6C3F1 mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.