Article
Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria.
Toxicology and applied pharmacology - 1 May 2004
Uno Shigeyuki, Dalton Timothy P, Sinclair Peter R, Gorman Nadia, Wang Bin, Smith Andrew G, Miller Marian L, Shertzer Howard G, Nebert Daniel W
Abstract excerpt
To study liver toxicity and uroporphyrin (URO) accumulation and urinary excretion, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a potent ligand for the aryl hydrocarbon receptor (AHR), is often used as the prototype. In this study, we asked the question how important is the role of CYP1A1 in causing TCDD toxicity. Using a single large intraperitoneal dose of TCDD (200 microg/kg) and following the response over an...
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