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Article

Impact of hepatic P450-mediated biotransformation on the disposition and respiratory tract toxicity of inhaled naphthalene.

Toxicology and applied pharmacology - 15 Aug 2017

Kovalchuk Nataliia, Kelty Jacklyn, Li Lei, Hartog Matthew, Zhang Qing-Yu, Edwards Patricia, Van Winkle Laura, Ding Xinxin

Abstract excerpt

We determined whether a decrease in hepatic microsomal cytochrome P450 activity would impact lung toxicity induced by inhalation exposure to naphthalene (NA), a ubiquitous environmental pollutant. The liver-Cpr-null (LCN) mouse showed decreases in microsomal metabolism of NA in liver, but not lung, compared to wild-type (WT) mouse. Plasma levels of NA and NA-glutathione conjugates (NA-GSH) were both higher in LCN...

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Identifiers

PMID: 28527914
DOI: 10.1016/j.taap.2017.05.015
PMCID: PMC6398949

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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