Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets.

Free radical biology & medicine - 15 Mar 2005

Traber Maret G, Siddens Lisbeth K, Leonard Scott W, Schock Bettina, Gohil Kishorchandra, Krueger Sharon K, Cross Carroll E, Williams David E

Abstract excerpt

Although all forms of vitamin E are absorbed, the liver preferentially secretes alpha-, but not gamma-tocopherol, into plasma. Liver alpha-tocopherol secretion is under the control of the alpha-tocopherol transfer protein (TTP). Therefore, to assess gamma-tocopherol bioactivities Ttpa-/-, +/- and +/+ mice were fed for 5 weeks diets containing gamma-tocopherol 550 (gamma-T550), gamma-tocopherol 60 (gamma-T60)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Tocopherol
Share to Animal Feed

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromans

Share to Cytochrome P-450 CYP3A

Share to Oxidoreductases, N-Demethylating

Share to Propionates

Share to Vitamin E

Share to Xenobiotics

Source

Identifiers

PMID: 15721988
DOI: 10.1016/j.freeradbiomed.2004.11.027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets.PMID 15721988Read ↗

Disruption of Mouse Cytochrome P450 4f14 (Cyp4f14 Gene) Causes Severe Perturbations in Vitamin E MetabolismSemantic proximity Read ↗

Dietary α‐tocopherol and neuromuscular health: Search for optimal dose and molecular mechanisms continues!Semantic proximity Read ↗

Alpha-tocopherol transport in the lung is affected by the apoE genotype--studies in transgenic apoE3 and apoE4 mice.Semantic proximity Read ↗

Vitamin E and Phosphoinositides Regulate the Intracellular Localization of the Hepatic α-Tocopherol Transfer Protein.Semantic proximity Read ↗

Molecular mechanisms of vitamin E transport.Semantic proximity Read ↗

Genetic deletion of Bco2 and Isx establishes a golden mouse model for carotenoid researchSemantic proximity Read ↗

Lipid peroxidation induced by carbon tetrachloride and its inhibition by antioxidant as evaluated by an oxidative stress marker, HODE.Semantic proximity Read ↗

Cytosolic persistence of mouse brain CYP1A1 in chronic heme deficiency.Semantic proximity Read ↗

The Effect of the BCO2 Genotype on the Expression of Genes Related to Carotenoid, Retinol, and α-Tocopherol Metabolism in Rabbits Fed a Diet with Aztec Marigold Flower Extract.Semantic proximity Read ↗

Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone.Semantic proximity Read ↗

Synthetic α-Tocopherol, Compared with Natural α-Tocopherol, Downregulates Myelin Genes in Cerebella of Adolescent Ttpa-null MiceSemantic proximity Read ↗

Impact of Glutathione Peroxidase-1 (Gpx1) Genotype on Selenoenzyme and Transcript Expression When Repleting Selenium-Deficient Mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.