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Article

The diabetes susceptibility locus Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2004

Greve Bernhard, Vijayakrishnan Lalitha, Kubal Aarup, Sobel Raymond A, Peterson Laurence B, Wicker Linda S, Kuchroo Vijay K

Abstract excerpt

Linkage analysis and congenic mapping in NOD mice have identified a susceptibility locus for type 1 diabetes, Idd5.1 on mouse chromosome 1, which includes the Ctla4 and Icos genes. Besides type 1 diabetes, numerous autoimmune diseases have been mapped to a syntenic region on human chromosome 2q33. In this study we determined how the costimulatory molecules encoded by these genes contribute to the...

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Share to Antigens, Differentiation
Share to Antigens, Differentiation, T-Lymphocyte

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CTLA-4 Antigen

Share to Diabetes Mellitus, Type 1

Share to Encephalomyelitis, Autoimmune, Experimental

Share to Inducible T-Cell Co-Stimulator Protein

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Share to Mice, Inbred NOD

Source

Identifiers

PMID: 15210770
DOI: 10.4049/jimmunol.173.1.157

Genes

ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The diabetes susceptibility locus Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitis.PMID 15210770Read ↗

Further mapping of the Idd5.1 locus for autoimmune diabetes in NOD mice.Semantic proximity Read ↗

Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.Semantic proximity Read ↗

NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.Semantic proximity Read ↗

Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes.Semantic proximity Read ↗

Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice.Semantic proximity Read ↗

Defective induction of CTLA-4 in the NOD mouse is controlled by the NOD allele of Idd3/IL-2 and a novel locus (Ctex) telomeric on chromosome 1.Semantic proximity Read ↗

Molecular genetic analysis of the Idd4 locus implicates the IFN response in type 1 diabetes susceptibility in nonobese diabetic mice.Semantic proximity Read ↗

The idd4 locus displays sex-specific epistatic effects on type 1 diabetes susceptibility in nonobese diabetic mice.Semantic proximity Read ↗

Gene-gene interactions in the NOD mouse model of type 1 diabetes.Semantic proximity Read ↗

Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci.Semantic proximity Read ↗

NOD alleles at Idd1 and Idd2 loci drive exocrine pancreatic inflammation.Semantic proximity Read ↗

Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice.Semantic proximity Read ↗

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