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Article

Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2.

Aging cell - 1 Dec 2005

Ayyadevara Srinivas, Dandapat Abhijit, Singh Sharda P, Benes Helen, Zimniak Ludwika, Shmookler Reis Robert J, Zimniak Piotr

Abstract excerpt

Electrophilic stress caused by lipid peroxidation products such as 4-hydroxynonenal (4-HNE) and/or related compounds may contribute to aging. The major mode of 4-HNE metabolism involves glutathione conjugation catalyzed by specialized glutathione transferases. We have previously shown that glutathione transferase CeGSTP2-2, the product of the Caenorhabditis elegans gst-10 gene, has the ability to conjugate 4-HNE,...

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PMID: 16300482
DOI: 10.1111/j.1474-9726.2005.00172.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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